Disulfiram Tablets

Last updated on RxList: 2/10/2021
Disulfiram Tablets Side Effects Center

Medical Editor: John P. Cunha, DO, FACOEP

What Is Disulfiram?

Disulfiram Tablets are an alcohol antagonist drug used as an aid in the management of selected chronic alcohol patients who want to remain in a state of enforced sobriety so that supportive and psychotherapeutic treatment may be applied to best advantage. Disulfiram Tablets are not a cure for alcoholism. When used alone, without proper motivation and supportive therapy, it is unlikely that it will have any substantive effect on the drinking pattern of the chronic alcoholic. Disulfiram is available in generic form.

What Are Side Effects of Disulfiram?

Common side effects of disulfiram include:

  • temporary mild drowsiness,
  • fatigue,
  • impotence,
  • headache,
  • acne,
  • allergic dermatitis, or
  • a metallic or garlic-like aftertaste may be experienced during the first two weeks of therapy.

Disulfiram plus alcohol, even in small amounts, may produce side effects including:

Dosage for Disulfiram

In the first phase of treatment, a maximum of 500 mg daily of disulfiram is given in a single dose for one to two weeks. The average maintenance dose of disulfiram is 250 mg daily (range, 125 to 500 mg), it should not exceed 500 mg daily. Disulfiram should never be administered until the patient has abstained from alcohol for at least 12 hours.

What Drugs, Substances, or Supplements Interact with Disulfiram?

Disulfiram may interact with alcohol, alcohol-containing preparations, phenytoin, metronidazole, paraldehyde, oral anticoagulants, isoniazid, and nitrites. Tell your doctor all medications and supplements you use.

Disulfiram During Pregnancy and Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant before using disulfiram; it is unknown if it will affects a fetus. It is unknown if disulfiram passes into breast milk. Because of the potential for adverse effects on a nursing infant, breastfeeding while taking disulfiram is not recommended. Withdrawal symptoms may occur if you suddenly stop taking this medication.

Additional Information

Our Disulfiram Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


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Disulfiram Tablets Consumer Information

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Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Even small amounts of alcohol can produce unpleasant symptoms while disulfiram is in your body. These symptoms include:

  • flushing (warmth, redness, or tingly feeling);
  • sweating, increased thirst, swelling, rapid weight gain;
  • nausea, severe vomiting;
  • neck pain, throbbing headache, blurred vision;
  • chest pain, shortness of breath (even with mild exertion);
  • fast or pounding heartbeats or fluttering in your chest;
  • confusion, weakness, spinning sensation, feeling unsteady; or
  • a light-headed feeling, like you might pass out.

More severe symptoms may occur when disulfiram and large amounts of alcohol are used together, such as severe chest pain spreading to your jaw or shoulder, slow heart rate, weak pulse, seizure, fainting, weak or shallow breathing, or slow breathing (breathing may stop). A disulfiram-alcohol reaction can be fatal.

Call your doctor at once if you have:

  • eye pain or sudden vision loss;
  • confusion, unusual thoughts or behavior; or
  • liver problems--nausea, upper stomach pain, itching, tired feeling, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).

Common side effects may include:

  • skin rash, acne;
  • mild headache, tired feeling;
  • impotence, loss of interest in sex; or
  • metallic or garlic-like taste in the mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Disulfiram Tablets (disulfiram)

Disulfiram Tablets Professional Information




Multiple cases of hepatitis, including both cholestatic and fulminant hepatitis, as well as hepatic failure resulting in transplantation or death, have been reported with administration of disulfiram.

Occasional skin eruptions are, as a rule, readily controlled by concomitant administration of an antihistaminic drug.

In a small number of patients, a transient mild drowsiness, fatigability, impotence, headache, acneform eruptions, allergic dermatitis, or a metallic or garlic-like aftertaste may be experienced during the first two weeks of therapy. These complaints usually disappear spontaneously with the continuation of therapy, or with reduced dosage.

Psychotic reactions have been noted, attributable in most cases to high dosage, combined toxicity (with metronidazole or isoniazid), or to the unmasking of underlying psychoses in patients stressed by the withdrawal of alcohol.

Read the entire FDA prescribing information for Disulfiram Tablets (disulfiram)

© Disulfiram Tablets Patient Information is supplied by Cerner Multum, Inc. and Disulfiram Tablets Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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