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Last reviewed on RxList: 4/3/2017
Diuril Side Effects Center

Last reviewed on RxList 01/19/2017

Diuril (chlorothiazide) is a thiazide diuretic (water pill) that treats fluid retention (edema) in people with congestive heart failure, cirrhosis of the liver, or kidney disorders, or edema caused by taking steroids or estrogen. Diuril is also used to treat high blood pressure (hypertension). Diuril is available in generic form. Common side effects of Diuril include:

Other side effects of Diuril include:

  • decreased sexual ability,
  • loss of interest in sex, or
  • increased sensitivity to the sun.

Diuril may cause a loss of too much body water (dehydration) and salt/minerals. Tell your doctor if you have unlikely but serious symptoms of dehydration or mineral loss including very dry mouth, thirst, muscle cramps, weakness, fast or irregular heartbeat, nausea, vomiting, severe dizziness, unusual drowsiness, unusual decrease in the amount of urine, fainting, confusion, seizures.

The usual adult dosage of Diuril for edema is 500 mg to 1000 mg (10 mL to 20 mL) once or twice a day. The usual adult starting dosage for hypertension is 500 mg or 1000 mg (10 mL to 20 mL) a day as a single or divided dose. Pediatric dose is determined by the child's weight. Diuril may interact with other medicines that cause lightheadedness (i.e., cold or allergy medicine, narcotics, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety), lithium, digoxin, cholestyramine, colestipol, steroids, other blood pressure medications, aspirin, NSAIDs (nonsteroidal anti-inflammatory drugs), insulin or oral diabetes medicines. Diuril should be used only when prescribed during pregnancy. This drug passes into breast milk. While there have been no reports of harm to nursing infants, consult your doctor before breastfeeding.

Our Diuril (chlorothiazide) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Diuril Consumer Information

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • nausea and vomiting with weakness, loss of appetite, headache, hallucinations, muscle pain, and/or seizure;
  • confusion, uneven heart rate, extreme thirst, leg discomfort, muscle weakness or limp feeling;
  • urinating more or less than usual or not at all;
  • easy bruising or bleeding;
  • numbness or tingly feeling;
  • fever, sore throat, and headache with a severe blistering, peeling, and red skin rash; or
  • jaundice (yellowing of the skin or eyes).

Less serious side effects may include:

  • dizziness, spinning sensation;
  • diarrhea, constipation, stomach cramps;
  • muscle spasm;
  • loss of interest in sex; or
  • blurred vision.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Diuril (Chlorothiazide)

Diuril Professional Information


The following adverse reactions have been reported and, within each category, are listed in order of decreasing severity.

Body as a Whole: Weakness.

Cardiovascular: Hypotension including orthostatic hypotension (may be aggravated by alcohol, barbiturates, narcotics or antihypertensive drugs).

Digestive: Pancreatitis, jaundice (intrahepatic cholestatic jaundice), diarrhea, vomiting, sialadenitis, cramping, constipation, gastric irritation, nausea, anorexia.

Hematologic: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia. Hypersensitivity: Anaphylactic reactions, necrotizing angiitis (vasculitis and cutaneous vasculitis), respiratory distress including pneumonitis and pulmonary edema, photosensitivity, fever, urticaria, rash, purpura.

Metabolic: Electrolyte imbalance (see PRECAUTIONS), hyperglycemia, glycosuria, hyperuricemia.

Musculoskeletal: Muscle spasm.

Nervous System/Psychiatric: Vertigo, paresthesias, dizziness, headache, restlessness.

Renal: Renal failure, renal dysfunction, interstitial nephritis. (See WARNINGS.)

Skin: Erythema multiforme including Stevens-Johnson syndrome, exfoliative dermatitis including toxic epidermal necrolysis, alopecia.

Special Senses: Transient blurred vision, xanthopsia.

Urogenital: Impotence.

Whenever adverse reactions are moderate or severe, thiazide dosage should be reduced or therapy withdrawn.

Read the entire FDA prescribing information for Diuril (Chlorothiazide)

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© Diuril Patient Information is supplied by Cerner Multum, Inc. and Diuril Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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