Medical Editor: John P. Cunha, DO, FACOEP
What Is Dobutamine?
Dobutamine Injection is a catecholamine indicated when parenteral therapy is necessary for inotropic support in the short-term treatment of adults with cardiac decompensation due to depressed contractility resulting either from organic heart disease or from cardiac surgical procedures. Dobutamine is available in generic form.
What Are Side Effects of Dobutamine?
Common side effects of dobutamine include:
- increased heart rate and increased blood pressure,
- ventricular ectopic activity,
- low platelet counts (thrombocytopenia), or
- swelling at the injection site.
Contact your doctor if you have serious side effects of dobutamine including:
- low blood pressure,
- chest pain (angina),
- fast or slow heartbeat,
- shortness of breath, or
- trouble breathing.
Dosage for Dobutamine
Dobutamine is administered in the form of injection. In patients who have atrial fibrillation with rapid ventricular response, a digitalis preparation should be used prior to institution of therapy with dobutamine. Infusion of dobutamine should be started at a low rate (0.5 to 1.0 mcg/kg/min) and titrated at intervals of a few minutes, guided by the patient's response. The rate of infusion of dobutamine needed to increase cardiac output usually ranges from 2.5 to 15 mcg/kg/min.
What Drugs, Substances, or Supplements Interact with Dobutamine?
Dobutamine may interact with beta-blockers and nitroprusside. Tell your doctor all medications and supplements you use.
Dobutamine During Pregnancy and Breastfeeding
Dobutamine should be used during pregnancy only if clearly needed. It is unknown if dobutamine passes into breast milk. If a mother requires dobutamine treatment, breastfeeding should be discontinued for the duration of the treatment.
Our Dobutamine Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Increased Heart Rate, Blood Pressure, And Ventricular Ectopic Activity
A 10- to 20-mm increase in systolic blood pressure and an increase in heart rate of 5 to 15 beats/minute have been noted in most patients (see WARNINGS regarding exaggerated chronotropic and pressor effects). Approximately 5% of patients have had increased premature ventricular beats during infusions. These effects are dose related.
Precipitous decreases in blood pressure have occasionally been described in association with dobutamine therapy. Decreasing the dose or discontinuing the infusion typically results in rapid return of blood pressure to baseline values. In rare cases, however, intervention may be required and reversibility may not be immediate.
Reactions At Sites Of Intravenous Infusion
Phlebitis has occasionally been reported. Local inflammatory changes have been described following inadvertent infiltration. Isolated cases of cutaneous necrosis (destruction of skin tissue) have been reported.
Miscellaneous Uncommon Effects
The following adverse effects have been reported in 1% to 3% of patients: nausea, headache, anginal pain, nonspecific chest pain, palpitations, and shortness of breath.
Isolated cases of thrombocytopenia have been reported.
Infusions of up to 72 hours have revealed no adverse effects other than those seen with shorter infusions.
Read the entire FDA prescribing information for Dobutamine (Dobutamine)
© Dobutamine Patient Information is supplied by Cerner Multum, Inc. and Dobutamine Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.