Medical Editor: John P. Cunha, DO, FACOEP Last updated on RxList: 11/9/2021
Dolobid Side Effects Center

What Is Dolobid?

Dolobid (diflunisal) Tablets is a nonsteroidal anti-inflammatory drug (NSAID) indicated for acute or long-term use for symptomatic treatment of mild to moderate pain, osteoarthritis, and rheumatoid arthritis. Dolobid is available in generic form.

What Are Side Effects of Dolobid?

Side effects of Dolobid include:

  • nausea,
  • stomach pain,
  • vomiting,
  • upset stomach,
  • diarrhea,
  • constipation,
  • gas,
  • dizziness,
  • drowsiness,
  • headache,
  • tired feeling,
  • sleep problems (insomnia), or
  • ringing in your ears.

Tell your doctor if you have serious side effects of Dolobid including:

  • bleeding from the stomach (can be fatal),
  • chest pain,
  • stroke,
  • shortness of breath,
  • stomach pain,
  • swelling of the hands or feet,
  • sudden or unexplained weight gain,
  • vision changes,
  • hearing changes (e.g., ringing in the ears),
  • mental/mood changes (e.g., confusion, hallucinations),
  • fast or pounding heartbeat,
  • persistent or severe headache,
  • fainting,
  • difficult or painful swallowing.

Dosage for Dolobid

Dolobid is available in 250 and 500 mg strength tablets. For mild to moderate pain, an initial dose of 1000 mg followed by 500mg every 12 hours is recommended for most patients. Following the initial dose,some patients may require 500 mg every 8 hours. For osteoarthritis and rheumatoid arthritis, the suggested dosage range is 500mg to 1000 mg daily in two divided doses. Tablets should be swallowed whole, not crushed or chewed.

What Drugs, Substances, or Supplements Interact with Dolobid?

Dolobid may interact with antacids, antidepressants, acetaminophen (Tylenol), blood thinners, cyclosporine, diuretics (water pills), lithium, methotrexate, or heart or blood pressure medications. Tell your doctor all medications and supplements you use.

Dolobid During Pregnancy or Breastfeeding

Tell your doctor if you are pregnant or plan to become pregnant during treatment with Dolobid. Taking Dolobid during the last 3 months of pregnancy may result in birth defects. Do not take Dolobid during pregnancy unless your doctor has told you to. Dolobid can pass into breast milk and may harm a nursing baby. Consult your doctor before breastfeeding.

Additional Information

Our Dolobid (diflunisal) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What joints are most often affected by osteoarthritis? See Answer
Dolobid Consumer Information

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Get emergency medical help if you have signs of an allergic reaction (hives, runny or stuffy nose, wheezing, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling).

Get emergency medical help if you have signs of a heart attack or stroke: chest pain spreading to your jaw or shoulder, sudden numbness or weakness on one side of the body, slurred speech, swelling in your legs, feeling short of breath.

Stop using diflunisal and call your doctor at once if you have:

  • changes in your vision;
  • any skin rash, no matter how mild;
  • shortness of breath (even with mild exertion);
  • swelling or rapid weight gain;
  • signs of stomach bleeding--bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;
  • liver problems--nausea, upper stomach pain, itching, tired feeling, flu-like symptoms, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
  • kidney problems--little or no urination, swelling in your feet or ankles, feeling tired; or
  • low red blood cells (anemia)--pale skin, unusual tiredness, feeling light-headed, cold hands and feet.

Common side effects may include:

  • nausea, vomiting, stomach pain, indigestion;
  • diarrhea, constipation, gas;
  • dizziness, drowsiness, headache, tired feeling;
  • rash; or
  • ringing in your ears.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Read the entire detailed patient monograph for Dolobid (Diflunisal)


Slideshow: Exercises for Knee Osteoarthritis and Joint Pain See Slideshow
Dolobid Professional Information


The adverse reactions observed in controlled clinical trials encompass observations in 2,427 patients.

Listed below are the adverse reactions reported in the 1,314 of these patients who received treatment in studies of two weeks or longer. Five hundred thirteen patients were treated for at least 24 weeks, 255 patients were treated for at least 48 weeks, and 46 patients were treated for 96 weeks. In general, the adverse reactions listed below were 2 to 14 times less frequent in the 1,113 patients who received short-term treatment for mild to moderate pain.

Incidence Greater Than 1%


The most frequent types of adverse reactions occurring with DOLOBID (diflunisal) are gastrointestinal: these include nausea** , vomiting, dyspepsia**, gastrointestinal pain**, diarrhea**, constipation, and flatulence.


  Somnolence, insomnia.

Central Nervous System


Special Senses





  Headache**, fatigue/tiredness.

Incidence Less Than 1 in 100

The following adverse reactions, occurring less frequently than 1 in 100, were reported in clinical trials or since the drug was marketed. The probability exists of a causal relationship between DOLOBID (diflunisal) and these adverse reactions.


Erythema multiforme, exfoliative dermatitis, Stevens-Johnson syndrome, toxic epidermal necrolysis, urticaria, pruritus, sweating, dry mucous membranes, stomatitis, photosensitivity.


Peptic ulcer, gastrointestinal bleeding, anorexia, eructation, gastrointestinal perforation, gastritis.
Liver function abnormalities; jaundice, sometimes with fever; cholestasis; hepatitis.


Thrombocytopenia; agranulocytosis; hemolytic anemia.


Dysuria; renal impairment, including renal failure; interstitial nephritis; hematuria; proteinuria.


Nervousness, depression, hallucinations, confusion, disorientation.

Central Nervous System

Vertigo; light-headedness; paresthesias.

Special Senses

Transient visual disturbances including blurred vision.

Hypersensitivity Reactions

Acute anaphylactic reaction with bronchospasm; angioedema; flushing.

Hypersensitivity vasculitis.

Hypersensitivity syndrome (see WARNINGS, Hypersensitivity Syndrome).


Asthenia, edema.

Causal Relationship Unknown

Other reactions have been reported in clinical trials or since the drug was marketed, but occurred under circumstances where a causal relationship could not be established. However, in these rarely reported events, that possibility cannot be excluded. Therefore, these observations are listed to serve as alerting information to physicians.




  Palpitation, syncope.


  Muscle cramps.


  Nephrotic syndrome.

Special Senses

 Hearing loss.


  Chest pain.

A rare occurrence of fulminant necrotizing fasciitis, particularly in association with Group A α-hemolytic streptococcus, has been described in persons treated with non-steroidal anti-inflammatory agents, including diflunisal, sometimes with fatal outcome (see also PRECAUTIONS, General).

Potential Adverse Effects

In addition, a variety of adverse effects not observed with DOLOBID (diflunisal) in clinical trials or in marketing experience, but reported with other non-steroidal analgesic/anti-inflammatory agents, should be considered potential adverse effects of DOLOBID (diflunisal) .

**Incidence between 3% and 9%. Those reactions occurring in 1% to 3% are not marked with an asterisk.

Read the entire FDA prescribing information for Dolobid (Diflunisal)

© Dolobid Patient Information is supplied by Cerner Multum, Inc. and Dolobid Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

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