Dopram Side Effects Center

Last updated on RxList: 5/10/2022
Dopram Side Effects Center

What Is Dopram?

Dopram (doxapram hydrochloride) Injection is a respiratory stimulant used to treat respiratory insufficiency due to drug overdose, surgery, or chronic pulmonary disease. Dopram is available in generic form.

What Are Side Effects of Dopram?

Common side effects of Dopram include:

Dosage for Dopram

The recommended dosage of Dopram is 0.5 – 1 mg/kg given every 5 minutes, not to exceed 2 mg/kg.

What Drugs, Substances, or Supplements Interact with Dopram?

General anesthesia, aminophylline, and theophylline may interact with Dopram. Before taking Dopram tell your doctor if you have impaired hepatic or renal function.

Dopram During Pregnancy or Breastfeeding

If you are pregnant only use Dopram if clearly needed. Exercise caution if you receive Dopram and are breastfeeding.

Additional Information

Our Dopram (doxapram hydrochloride) Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


Health Screening Tests Every Woman Needs See Slideshow
Dopram Professional Information


Adverse reactions reported coincident with the administration of DOPRAM (doxapram hydrochloride, USP)

Central And Autonomic Nervous Systems

Pyrexia, flushing, sweating; pruritus and paresthesia, such as a feeling of warmth, burning, or hot sensation, especially in the area of genitalia and perineum; apprehension, disorientation, pupillary dilatation, hallucinations, headache, dizziness, hyperactivity, involuntary movements, muscle spasticity, muscle fasciculations, increased deep tendon reflexes, clonus, bilateral Babinski, and convulsions.


Dyspnea, cough, hyperventilation, tachypnea, laryngospasm, bronchospasm, hiccough, and rebound hypoventilation.


Phlebitis, variations in heart rate, lowered T-waves, arrhythmias (including ventricular tachycardia and ventricular fibrillation), chest pain, tightness in chest. A mild to moderate increase in blood pressure is commonly noted and may be of concern in patients with severe cardiovascular diseases.


Nausea, vomiting, diarrhea, desire to defecate.


Stimulation of urinary bladder with spontaneous voiding; urinary retention. Elevation of BUN and albuminuria.

Hemic And Lymphatic

Hemolysis with rapid infusion. A decrease in hemoglobin, hematocrit, or red blood cell count has been observed in postoperative patients. In the presence of pre-existing leukopenia, a further decrease in WBC has been observed following anesthesia and treatment with doxapram hydrochloride.


Administration of doxapram to patients who are receiving sympathomimetic or monoamine oxidase inhibiting drugs may result in an additive pressor effect (see PRECAUTIONS, General).

In patients who have received neuromuscular blocking agents, doxapram may temporarily mask the residual effects of these drugs.

In patients who have received general anesthesia utilizing a volatile agent known to sensitize the myocardium to catecholamines, administration of doxapram should be delayed until the volatile agent has been excreted in

order to lessen the potential for arrhythmias, including ventricular tachycardia and ventricular fibrillation (see WARNINGS).

There may be an interaction between doxapram and aminophylline and between doxapram and theophylline manifested by increased skeletal muscle activity, agitation, and hyperactivity.

Read the entire FDA prescribing information for Dopram (Doxapram)

© Dopram Patient Information is supplied by Cerner Multum, Inc. and Dopram Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights.

Health Solutions From Our Sponsors