Dovato vs. Genvoya, Stribild

Reviewed on 11/12/2019

Are Dovato and Genvoya, Stribild the Same Thing?

Dovato (dolutegravir and lamivudine) and Genvoya, Stribild (elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide) are used as complete regimens to treat human immunodeficiency virus type 1 (HIV-1) infection with no antiretroviral treatment history and with no known substitutions associated with resistance to the individual components of either drug.

Dovato and Genvoya, Stribild both contain combinations of integrase strand transfer inhibitors (INSTIs) and nucleoside analogue reverse transcriptase inhibitors (NRTIs). Genvoya, Stribild also contains a CYP3A inhibitor.

Side effects of Dovato and Genvoya, Stribild that are similar include headache, diarrhea, nausea, and fatigue.

Side effects of Dovato that are different from Genvoya, Stribild include insomnia and dizziness.

Side effects of Genvoya, Stribild that are different from Dovato include body fat redistribution.

Both Dovato and Genvoya, Stribild may interact with other antiretroviral medications and St. John's wort.

Dovato may also interact with dofetilide, metformin, anticonvulsants, rifampin, cation-containing antacids or laxatives, sucralfate, buffered medications, oral calcium and iron supplements (including multivitamins containing calcium or iron), and sorbitol.

Genvoya, Stribild may also interact with drugs metabolized by CYP3A or CYP2D6, alpha 1-adrenoreceptor antagonists, anticonvulsants, antimycobacterials, ergot derivatives, cisapride, HMG-CoA reductase inhibitors (“statins”), pimozide, sildenafil, and sedative/hypnotics.

What Are Possible Side Effects of Dovato?

Common side effects of Dovato include:

  • headache,
  • diarrhea,
  • nausea,
  • insomnia,
  • fatigue, and
  • dizziness

What Are Possible Side Effects of Genvoya, Stribild?

Common side effects of Genvoya, Stribild include:

  • nausea,
  • diarrhea,
  • fatigue,
  • headache, and
  • body fat redistribution.

Serious side effects of Genvoya include lactic acidosis. Tell your doctor if you have symptoms of lactic acidosis such as weakness, unusual muscle pain, difficulty breathing, feeling cold in the extremities, dizziness, lightheadedness, or fast or irregular heartbeat.

What Is Dovato?

Dovato (dolutegravir and lamivudine) is a combination of an integrase strand transfer inhibitor (INSTI) and a nucleoside analogue reverse transcriptase inhibitor (NRTI) indicated as a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults with no antiretroviral treatment history and with no known substitutions associated with resistance to the individual components of Dovato.

What Is Genvoya, Stribild?

Genvoya, Stribild (elvitegravir, cobicistat, emtricitabine, and tenofovir alafenamide) is a four-drug combination of an HIV-1 integrase strand transfer inhibitor (INSTI), a CYP3A inhibitor, and two HIV-1 nucleoside analog reverse transcriptase inhibitors (NRTIs) and is indicated as a complete regimen for the treatment of HIV-1 infection in adults and pediatric patients 12 years of age and older who have no antiretroviral treatment history or to replace the current antiretroviral regimen in those who are virologically-suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen for at least 6 months with no history of treatment failure and no known substitutions associated with resistance to the individual components of Genvoya.

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What Drugs Interact With Dovato?

Dovato may interact with other antiretroviral drugs for the treatment of HIV-1 infection, dofetilide, metformin, anticonvulsants, rifampin, St. John's wort, cation-containing antacids or laxatives, sucralfate, buffered medications, oral calcium and iron supplements (including multivitamins containing calcium or iron), and sorbitol.

What Drugs Interact With Genvoya, Stribild?

Genvoya, Stribild may interact with other antiretroviral medications, drugs metabolized by CYP3A or CYP2D6, alpha 1-adrenoreceptor antagonists, anticonvulsants, antimycobacterials, ergot derivatives, St. John's wort, cisapride, HMG-CoA reductase inhibitors, pimozide, sildenafil, and sedative/hypnotics. Tell your doctor all medications and supplements you use. During pregnancy, Genvoya should be used only if prescribed. Tell your doctor if you are pregnant before taking Genvoya. Women infected with HIV should not breastfeed due to the potential for HIV transmission.

How Should Dovato Be Taken?

The dose of Dovato is one tablet taken orally once daily with or without food.

How Should Genvoya, Stribild Be Taken?

The recommended dosage of Genvoya, Stribild is one tablet taken orally once daily with food. Prior to taking Genvoya, patients should be tested for hepatitis B infection.

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References
ViiV Healthcare. Dovato Product Monograph.

https://www.dovato.com

Gilead. Genvoya Product Information.

https://www.genvoya.com

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