Are Dovato and Juluca the Same Thing?
Dovato (dolutegravir and lamivudine) and Juluca (dolutegravir and rilpivirine) are combinations of integrase strand transfer inhibitors (INSTIs) and nucleoside analogue reverse transcriptase inhibitors (NRTIs) used as complete regimens to treat human immunodeficiency virus type 1 (HIV-1) infection in adults with no antiretroviral treatment history and with no known substitutions associated with resistance to the individual components of either drug.
Both Dovato and Juluca may interact with other antiretroviral medications, dofetilide, metformin, anticonvulsants, St. John's wort, some antacids, cation-containing products or laxatives, sucralfate, buffered medications, and oral calcium and iron supplements (including multivitamins containing calcium or iron).
What Are Possible Side Effects of Dovato?
Common side effects of Dovato include:
- fatigue, and
What Are Possible Side Effects of Juluca?
Common side effects of Juluca include:
- diarrhea and
- other antiretroviral medications,
- H2-receptor antagonists,
- St John's wort,
- macrolide or ketolide antibiotics,
- cation-containing products or laxatives,
- buffered medications,
- narcotic analgesics,
- oral calcium and iron supplements (including multivitamins containing calcium or iron),
- and proton pump inhibitors (PPIs).
What Is Dovato?
Dovato (dolutegravir and lamivudine) is a combination of an integrase strand transfer inhibitor (INSTI) and a nucleoside analogue reverse transcriptase inhibitor (NRTI) indicated as a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults with no antiretroviral treatment history and with no known substitutions associated with resistance to the individual components of Dovato.
What Is Juluca?
Juluca (dolutegravir and rilpivirine) is a combination of a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI) and an HIV-1non-nucleoside reverse transcriptase inhibitor (NNRTI) indicated as a complete regimen for the treatment of HIV-1 infection in adults to replace the current antiretroviral regimen in those who are virologically suppressed (HIV-1 RNA less than 50 copies per mL) on a stable antiretroviral regimen for at least 6months with no history of treatment failure and no known substitutions associated with resistance to the individual components of Juluca.
What Drugs Interact With Dovato?
Dovato may interact with other antiretroviral drugs for the treatment of HIV-1 infection, dofetilide, metformin, anticonvulsants, rifampin, St. John's wort, cation-containing antacids or laxatives, sucralfate, buffered medications, oral calcium and iron supplements (including multivitamins containing calcium or iron), and sorbitol.
What Drugs Interact With Juluca?
Tell your doctor all medications and supplements you use. Tell your doctor if you are pregnant or plan to become pregnant before using Juluca; it is unknown how it would affect a fetus. There is a pregnancy exposure registry that monitors pregnancy outcomes in women exposed to Juluca during pregnancy. It is unknown if Juluca passes into breast milk, however, breastfeeding is not recommended due to the potential for HIV transmission.
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ViiV. Juluca Product Information.