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Dovato vs. Truvada

Reviewed on 11/12/2019

Are Dovato and Truvada the Same Thing?

Dovato (dolutegravir and lamivudine) and Truvada (emtricitabine/tenofovir disoproxil fumarate) are used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS).

Dovato and Truvada both contain nucleoside analogue reverse transcriptase inhibitors (NRTIs). Dovato also contains an integrase strand transfer inhibitor (INSTI).

Side effects of Dovato and Truvada that are similar include headache, diarrhea, nausea, insomnia, and dizziness.

Side effects of Dovato that are different from Truvada include fatigue.

Side effects of Truvada that are different from Dovato include vomiting, stomach pain, depression, joint pain, strange dreams, back pain, itching or skin rash, changes in the color of skin on your palms or soles of your feet, and changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Both Dovato and Truvada may interact with other antiretroviral drugs.

Dovato may also interact with dofetilide, metformin, anticonvulsants, rifampin, St. John's wort, cation-containing antacids or laxatives, sucralfate, buffered medications, oral calcium and iron supplements (including multivitamins containing calcium or iron), and sorbitol.

Truvada may also interact with lithium, methotrexate, pain or arthritis medicines, medicines used to prevent organ transplant rejection, IV antibiotics, cancer medicines, herpes medications, medications to treat cytomegalovirus (CMV), and other HIV medicines.

What Are Possible Side Effects of Dovato?

Common side effects of Dovato include:

  • headache,
  • diarrhea,
  • nausea,
  • insomnia,
  • fatigue, and
  • dizziness

What Are Possible Side Effects of Truvada?

Common side effects of Truvada include:

  • nausea,
  • vomiting,
  • stomach pain,
  • diarrhea,
  • headache,
  • dizziness,
  • depression,
  • joint pain,
  • trouble sleeping,
  • strange dreams,
  • back pain,
  • itching or skin rash,
  • changes in the color of skin on your palms or soles of your feet, or
  • changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).

Tell your doctor if you have serious side effects of Truvada including:

  • mental/mood changes (such as depression, anxiety),
  • loss of appetite,
  • stomach or abdominal pain,
  • pink or bloody urine, or
  • changes in the amount of urine.

What Is Dovato?

Dovato (dolutegravir and lamivudine) is a combination of an integrase strand transfer inhibitor (INSTI) and a nucleoside analogue reverse transcriptase inhibitor (NRTI) indicated as a complete regimen for the treatment of human immunodeficiency virus type 1 (HIV-1) infection in adults with no antiretroviral treatment history and with no known substitutions associated with resistance to the individual components of Dovato.

What Is Truvada?

Truvada (emtricitabine/tenofovir disoproxil fumarate) is a combination of antiviral drugs used to treat HIV, which causes acquired immunodeficiency syndrome (AIDS). Truvada is not a cure for HIV or AIDS.

SLIDESHOW

A Timeline of the HIV/AIDS Pandemic See Slideshow

What Drugs Interact With Dovato?

Dovato may interact with other antiretroviral drugs for the treatment of HIV-1 infection, dofetilide, metformin, anticonvulsants, rifampin, St. John's wort, cation-containing antacids or laxatives, sucralfate, buffered medications, oral calcium and iron supplements (including multivitamins containing calcium or iron), and sorbitol.

What Drugs Interact With Truvada?

Truvada may interact with lithium, methotrexate, pain or arthritis medicines, medicines used to prevent organ transplant rejection, IV antibiotics, antiviral medicines, cancer medicines, herpes medications, medications to treat cytomegalovirus (CMV), or other HIV medicines. Tell your doctor all medications and supplements you use. During pregnancy, Truvada should be used only when prescribed. It is normal to prescribe HIV medicines such as Truvada for pregnant women with HIV. This can decrease the risk of passing HIV to the baby. Truvada may be part of that treatment. Consult your doctor. It is unknown if Truvada passes into breast milk. Because breast milk can transmit HIV, do not breastfeed.

How Should Dovato Be Taken?

The dose of Dovato is one tablet taken orally once daily with or without food.

How Should Truvada Be Taken?

The dose of Truvada for adults and pediatric patients 12 years of age and older with body weight 35 kg (77 lb) or more is one tablet (200 mg of emtricitabine and 300 mg of tenofovir disoproxil fumarate) once daily taken orally with or without food.

QUESTION

What is HIV? See Answer
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References
ViiV Healthcare. Dovato Product Monograph.

https://www.dovato.com

Gilead. Truvada Product Information.

https://www.truvada.com

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