ampicillin-sulbactam iv brand names and other generic formulations include:
Unasyn IV
methotrexate brand names and other generic formulations include:
No brand names available
ampicillin-sulbactam iv and methotrexate
ampicillin-sulbactam iv increases levels of methotrexate by reducing drug clearance through the kidneys. Blood levels of methotrexate may increase.
ampicillin-sulbactam iv and methotrexate
ampicillin-sulbactam iv increases levels of methotrexate by decreasing renal clearance. Increased serum concentrations of methotrexate with concomitant hematologic and gastrointestinal toxicity have been observed with concurrent administration of high or low doses of methotrexate and penicillins.
Check for more interactions with the Drug Interaction Checker
Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant