Drug interactions with ampicillin-sulbactam iv and methotrexate sodium oral

ampicillin-sulbactam iv brand names and other generic formulations include:

Unasyn IV

All generic drug interactions for ampicillin-sulbactam iv (lists will include brand and generic names):

methotrexate sodium oral brand names and other generic formulations include:

Methotrexate (Anti-Rheumatic) Oral, Rheumatrex Oral, Trexall Oral

All generic drug interactions for methotrexate sodium oral (lists will include brand and generic names):
Monitor CloselySignificant interaction possible (monitoring by your doctor required)

ampicillin-sulbactam iv and methotrexate sodium oral

ampicillin-sulbactam iv increases levels of methotrexate sodium oral by reducing drug clearance through the kidneys. Blood levels of methotrexate may increase.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Monitor CloselyUse Caution/Monitor.

ampicillin-sulbactam iv and methotrexate sodium oral

ampicillin-sulbactam iv increases levels of methotrexate sodium oral by decreasing renal clearance. Increased serum concentrations of methotrexate with concomitant hematologic and gastrointestinal toxicity have been observed with concurrent administration of high or low doses of methotrexate and penicillins.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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