Drug interactions with aspirin-acetaminophen (buffered) oral and methotrexate

aspirin-acetaminophen (buffered) oral brand names and other generic formulations include:

Excedrin Back & Body Oral

All generic drug interactions for aspirin-acetaminophen (buffered) oral (lists will include brand and generic names):

methotrexate brand names and other generic formulations include:

No brand names available

All generic drug interactions for methotrexate (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

aspirin-acetaminophen (buffered) oral and methotrexate

aspirin-acetaminophen (buffered) oral increases levels of methotrexate by reducing drug clearance through the kidneys. Blood levels of methotrexate may be increased leading to serious adverse effects.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Serious - Use AlternativeAvoid or Use Alternate Drug.

aspirin-acetaminophen (buffered) oral and methotrexate

aspirin-acetaminophen (buffered) oral increases levels of methotrexate by decreasing renal clearance. Caution should be exercised when salicylates are given in combination with methotrexate. Risk for drug interactions with methotrexate is greatest during high-dose methotrexate therapy, it has been recommended that any of these drugs be used cautiously with methotrexate even when methotrexate is used in low doses.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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