
bosentan oral brand names and other generic formulations include:
clopidogrel oral brand names and other generic formulations include:
bosentan oral and clopidogrel oral
bosentan oral will decrease the level or effect of clopidogrel oral by altering drug metabolism. The effect of clopidogrel may increase and may increase risk of bleeding.
bosentan oral and clopidogrel oral
bosentan oral will decrease the level or effect of clopidogrel oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. CYP3A4 inducers may increase the metabolism of clopidogrel to its active metabolite. Monitor patients for potential increase in antiplatelet effects when CYP3A4 inducers are used in combination with clopidogrel
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant