
bosentan oral brand names and other generic formulations include:
cobicistat oral brand names and other generic formulations include:
Tybost Oral
bosentan oral and cobicistat oral
bosentan oral will decrease the level or effect of cobicistat oral by altering drug metabolism. You doctor may need to decrease your dosage of bosentan.
bosentan oral and cobicistat oral
bosentan oral will decrease the level or effect of cobicistat oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Bosentan dose reduction required. Refer to the prescribing information of bosentan and cobicistat for recommended dosage adjustments.
Check for more interactions with the Drug Interaction Checker
Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant