bosentan oral brand names and other generic formulations include:
fentanyl sublingual brand names and other generic formulations include:
No brand names available
bosentan oral and fentanyl sublingual
bosentan oral will decrease the level or effect of fentanyl sublingual by altering drug metabolism. Combination increases the risk of bleeding. Dose of heparin may be reduced by your doctor.
bosentan oral and fentanyl sublingual
bosentan oral will decrease the level or effect of fentanyl sublingual by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Coadministration of fentanyl with CYP3A4 inducers could lead to a decrease in fentanyl plasma concentrations, lack of efficacy or, possibly, development of a withdrawal syndrome in a patient who has developed physical dependence to fentanyl. After stopping a CYP3A4 inducer, as the effects of the inducer decline, the fentanyl plasma concentration will increase which could increase or prolong both the therapeutic and adverse effects.
Check for more interactions with the Drug Interaction Checker
Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant