
bosentan oral brand names and other generic formulations include:
gefitinib oral brand names and other generic formulations include:
bosentan oral and gefitinib oral
bosentan oral will decrease the level or effect of gefitinib oral by altering drug metabolism.
bosentan oral and gefitinib oral
bosentan oral will decrease the level or effect of gefitinib oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Increase gefitinib to 500 mg daily if coadministered with a strong CYP3A4 inducer. Resume gefitinib dose at 250 mg/day 7 days after discontinuing the strong inducer.
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant