Drug interactions with bosentan oral and hydrocodone-ibuprofen oral

bosentan oral brand names and other generic formulations include:

Tracleer Oral

All generic drug interactions for bosentan oral (lists will include brand and generic names):

hydrocodone-ibuprofen oral brand names and other generic formulations include:

Ibudone Oral, Reprexain Oral, Vicoprofen Oral, Xylon 10 Oral

All generic drug interactions for hydrocodone-ibuprofen oral (lists will include brand and generic names):
Monitor CloselyPotential for significant interaction (monitoring by your doctor is likely required)

bosentan oral and hydrocodone-ibuprofen oral

bosentan oral will decrease the level or effect of hydrocodone-ibuprofen oral by altering drug metabolism. Blood levels of hydrocodone may be reduced but may increase upon stopping the interacting drug which can result in potentially life-threatening respiratory depression (difficulty breathing).

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Monitor CloselyModify Therapy/Monitor Closely.

bosentan oral and hydrocodone-ibuprofen oral

bosentan oral will decrease the level or effect of hydrocodone-ibuprofen oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Caution when discontinuing CYP3A4 inducers that are coadministered with hydrocodone; plasma concentrations of hydrocodone may increase and can result in potentially fatal respiratory depression

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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