bosentan oral brand names and other generic formulations include:
sildenafil iv brand names and other generic formulations include:
Revatio IV
bosentan oral and sildenafil iv
bosentan oral will decrease the level or effect of sildenafil iv by altering drug metabolism. Blood levels of sildenafil may be reduced.
bosentan oral and sildenafil iv
bosentan oral will decrease the level or effect of sildenafil iv by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Potent CYP3A4 inducers are expected to cause substantial decreases in sildenafil plasma levels
Check for more interactions with the Drug Interaction Checker
Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant