
bosentan oral brand names and other generic formulations include:
tofacitinib oral brand names and other generic formulations include:
bosentan oral and tofacitinib oral
bosentan oral will decrease the level or effect of tofacitinib oral by altering drug metabolism. Effect of tofacitinib may be reduced.
bosentan oral and tofacitinib oral
bosentan oral will decrease the level or effect of tofacitinib oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Loss of, or decreased response to tofacitinib may occur when coadministered with potent CYP3A4 inducers
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant