captopril-hydrochlorothiazide oral brand names and other generic formulations include:
topotecan iv brand names and other generic formulations include:
captopril-hydrochlorothiazide oral and topotecan iv
captopril-hydrochlorothiazide oral will increase the level or effect of topotecan iv by affects how the drug is eliminated from the body (via what is known as the P-glycoprotein [MDR1] transporter). Blood levels of topotecan may be reduced; the interaction with IV topotecan may be less severe but is still likely of clinical significance.
captopril-hydrochlorothiazide oral and topotecan iv
captopril-hydrochlorothiazide oral will increase the level or effect of topotecan iv by P-glycoprotein (MDR1) efflux transporter. Product labeling for PO topotecan recommends avoiding concomitant use of P-gp inhibitors; the interaction with IV topotecan may be less severe but is still likely of clinical significance
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant