Drug interactions with ceritinib oral and phenytoin sodium extended oral

ceritinib oral brand names and other generic formulations include:

Zykadia Oral

All generic drug interactions for ceritinib oral (lists will include brand and generic names):

phenytoin sodium extended oral brand names and other generic formulations include:

Dilantin Extended Oral, Dilantin Kapseal Oral, Diphentoin Extended Oral, Phenytek Oral, Phenytex Extended Oral

All generic drug interactions for phenytoin sodium extended oral (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

ceritinib oral and phenytoin sodium extended oral

ceritinib oral increases levels of phenytoin sodium extended oral by altering drug metabolism. Ceritinib increases blood levels of drugs that are eliminated by liver breakdown. If use of these medications is unavoidable your doctor will consider dose reduction.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Serious - Use AlternativeAvoid or Use Alternate Drug.

ceritinib oral and phenytoin sodium extended oral

ceritinib oral increases levels of phenytoin sodium extended oral by affecting hepatic enzyme CYP2C9/10 metabolism. Avoid concurrent use of CYP2C9 substrates known to have narrow therapeutic indices or substrates primarily metabolized by CYP2C9 during treatment with ceritinib; if use of these medications is unavoidable, consider dose

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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