ceritinib oral brand names and other generic formulations include:
Zykadia Oral
sirolimus oral brand names and other generic formulations include:
ceritinib oral and sirolimus oral
ceritinib oral increases levels of sirolimus oral by altering drug metabolism. Ceritinib increases blood levels of drugs that are eliminated by liver breakdown. If use of these medications is unavoidable your doctor will consider dose reduction.
ceritinib oral and sirolimus oral
ceritinib oral increases levels of sirolimus oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid concurrent use of CYP3A substrates known to have narrow therapeutic indices or substrates primarily metabolized by CYP3A during treatment with ceritinib; if use of these medications is unavoidable, consider dose
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant