
cyclosporine modified oral brand names and other generic formulations include:
Gengraf Oral, Neoral Oral, SangCya Oral
aliskiren oral brand names and other generic formulations include:
cyclosporine modified oral and aliskiren oral
cyclosporine modified oral will increase the level or effect of aliskiren oral by altering drug metabolism. Blood levels of aliskiren may increase.
cyclosporine modified oral and aliskiren oral
cyclosporine modified oral will increase the level or effect of aliskiren oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid concurrent use. Coadministration of 200 mg and 600 mg cyclosporine, with 75 mg aliskiren resulted in an approximately 2.5-fold increase in Cmax and 5-fold increase in AUC of aliskiren
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant