Drug interactions with dabrafenib oral and cabozantinib oral

dabrafenib oral brand names and other generic formulations include:

Tafinlar Oral

All generic drug interactions for dabrafenib oral (lists will include brand and generic names):

cabozantinib oral brand names and other generic formulations include:

Cometriq Oral

All generic drug interactions for cabozantinib oral (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

dabrafenib oral and cabozantinib oral

dabrafenib oral will decrease the level or effect of cabozantinib oral by altering drug metabolism. Avoid combining cabozantinib with drugs that increase its breakdown. If it is combined with such drugs, increase the cabozantinib dose by 40 mg/day or by 20 mg/day. Resume the previous dose 2-3 days after the interacting drug is stopped.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Serious - Use AlternativeAvoid or Use Alternate Drug.

dabrafenib oral and cabozantinib oral

dabrafenib oral will decrease the level or effect of cabozantinib oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration of cabozantinib with strong CYP3A4 inducers. If a strong CYP3A4 inducer is required, increase cabozantinib dose by 40 mg/day (Cometriq) or by 20 mg/day (Cabometyx). Resume previous dose 2-3 days after strong CYP3A4 inducer discontinued.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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