
dabrafenib oral brand names and other generic formulations include:
Tafinlar Oral
ibrutinib oral brand names and other generic formulations include:
Imbruvica Oral
dabrafenib oral and ibrutinib oral
dabrafenib oral decreases levels of ibrutinib oral by altering drug metabolism. Ibrutinib blood concentrations may decrease by ~10-fold.
dabrafenib oral and ibrutinib oral
dabrafenib oral decreases levels of ibrutinib oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Strong CYP3A inducers decrease ibrutinib plasma concentrations by ~10-fold
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant