Drug interactions with doxylamine-phenylephrine-dextromethorphan-acetaminophen oral and sodium oxybate oral

doxylamine-phenylephrine-dextromethorphan-acetaminophen oral brand names and other generic formulations include:

Alka-Seltzer Plus Day-Night (acetaminophen) Oral, Alka-Seltzer Plus Night Oral, Alka-Seltzer Plus Sinus-Allergy-Cgh Oral, Cold & Flu Relief Plus (Day/Night) Oral, Cold Multi-Symptom NightTime Oral, Cold-Flu Relief, Day/Night Oral, Daytime-Nighttime Cold-Flu Oral, Daytime-Nighttime Oral, Delsym Multi-Symptom Oral, DM-PE-acetaminophen/DM-acetaminophen-doxylamine Oral, Mucinex Fast-Max Nite Cold & Flu (doxylamine) Oral, Nite Time Cold-Flu Relief (phenylephrine) Oral, Severe Cold & Flu Nighttime Oral, Severe Sinus Congestion Allergy-Cough Oral, Vicks DayQuil-NyQuil Cold-Flu Oral, Vicks DayQuil-NyQuil Oral, Vicks NyQuil Severe Cold-Flu Oral

All generic drug interactions for doxylamine-phenylephrine-dextromethorphan-acetaminophen oral (lists will include brand and generic names):

sodium oxybate oral brand names and other generic formulations include:

Xyrem Oral

All generic drug interactions for sodium oxybate oral (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

doxylamine-phenylephrine-dextromethorphan-acetaminophen oral and sodium oxybate oral

doxylamine-phenylephrine-dextromethorphan-acetaminophen oral , sodium oxybate oral . Either increases the level of the other by added drug effects. Combination increases risk of CNS (central nervous system) depression.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Serious - Use AlternativeAvoid or Use Alternate Drug.

doxylamine-phenylephrine-dextromethorphan-acetaminophen oral and sodium oxybate oral

doxylamine-phenylephrine-dextromethorphan-acetaminophen oral , sodium oxybate oral . Either increases effects of the other by pharmacodynamic synergism. Profound sedation, respiratory depression, coma, and death may result if coadministered. Reserve concomitant prescribing of these drugs in patients for whom other treatment options are inadequate. Limit dosages and durations to the minimum required. Monitor closely for signs of respiratory depression and sedation.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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