efavirenz-emtricitabin-tenofovir oral brand names and other generic formulations include:
voriconazole iv brand names and other generic formulations include:
Vfend IV IV
efavirenz-emtricitabin-tenofovir oral and voriconazole iv
efavirenz-emtricitabin-tenofovir oral decreases effects of voriconazole iv by altering drug metabolism. Efavirenz doses ≥400 mg/day resulting in decreased voriconazole levels.
efavirenz-emtricitabin-tenofovir oral and voriconazole iv
efavirenz-emtricitabin-tenofovir oral decreases effects of voriconazole iv by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindication applies to efavirenz doses of 400 mg/day or higher. This dose of efavirenz induces CYP3A4 resulting in decreased voriconazole levels. When voriconazole is coadministered with efavirenz, voriconazole oral maintenance dose should be increased to 400 mg q12hr and efavirenz should be decreased to 300 mg q24hr.
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant