Drug interactions with esomeprazole magnesium oral and atazanavir oral

esomeprazole magnesium oral brand names and other generic formulations include:

Nexium 24HR Oral, Nexium Oral, Nexium Packet Oral

All generic drug interactions for esomeprazole magnesium oral (lists will include brand and generic names):

atazanavir oral brand names and other generic formulations include:

Reyataz Oral

All generic drug interactions for atazanavir oral (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

esomeprazole magnesium oral and atazanavir oral

esomeprazole magnesium oral will decrease the level or effect of atazanavir oral by reducing stomach acidity. This interaction may occur when both drugs are taken by mouth. Proton pump inhibitors (PPI) reduce blood levels of atazanavir. PPI dose should not exceed a dose comparable to omeprazole 20 mg and must be taken about 12 hours before atazanavir in patients who just started atazanavir. PPIs are not recommended in people who have been taking atazanavir for some time.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Serious - Use AlternativeAvoid or Use Alternate Drug.

esomeprazole magnesium oral and atazanavir oral

esomeprazole magnesium oral will decrease the level or effect of atazanavir oral by increasing gastric pH. Applies only to oral form of both agents. Atazanavir solubility decreases as pH increases. Substantially reduced plasma concentrations of atazanavir are expected if PPIs are coadministered. PPI dose should not exceed a dose comparable to omeprazole 20 mg and must be taken ~12 h before atazanavir/ritonavir in treatment naive-patients. PPIs are not recommended in treatment-experienced taking atazanavir.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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