Drug interactions with glycerol phenylbutyrate oral and midazolam oral

glycerol phenylbutyrate oral brand names and other generic formulations include:

Ravicti Oral

All generic drug interactions for glycerol phenylbutyrate oral (lists will include brand and generic names):

midazolam oral brand names and other generic formulations include:

Versed Oral

All generic drug interactions for midazolam oral (lists will include brand and generic names):
Monitor CloselySignificant interaction possible (monitoring by your doctor required)

glycerol phenylbutyrate oral and midazolam oral

glycerol phenylbutyrate oral will decrease the level or effect of midazolam oral by altering drug metabolism. Glycerol phenylbutyrate may reduce blood levels and effect of certain drugs, for example, midazolam.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Monitor CloselyUse Caution/Monitor.

glycerol phenylbutyrate oral and midazolam oral

glycerol phenylbutyrate oral will decrease the level or effect of midazolam oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Glycerol phenylbutyrate is a weak inducer of CYP3A4. Monitor for decreased efficacy of CYP3A4 substrates that have a narrow therapeutic index. Cmax and AUC were 25% and 32% lower for a single dose of midazolam after multiple doses of glycerol phenylbutyrate.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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