Drug interactions with ibuprofen-famotidine oral and ledipasvir-sofosbuvir oral

ibuprofen-famotidine oral brand names and other generic formulations include:

Duexis Oral

All generic drug interactions for ibuprofen-famotidine oral (lists will include brand and generic names):

ledipasvir-sofosbuvir oral brand names and other generic formulations include:

Harvoni Oral

All generic drug interactions for ledipasvir-sofosbuvir oral (lists will include brand and generic names):
Monitor CloselySignificant interaction possible (monitoring by your doctor required)

ibuprofen-famotidine oral and ledipasvir-sofosbuvir oral

ibuprofen-famotidine oral decreases levels of ledipasvir-sofosbuvir oral by Other mechanism. Blood levels of ledipasvir may decrease. Take them 12 hours apart or at the same time.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Monitor CloselyUse Caution/Monitor.

ibuprofen-famotidine oral and ledipasvir-sofosbuvir oral

ibuprofen-famotidine oral decreases levels of ledipasvir-sofosbuvir oral by Other (see comment). Ledipasvir solubility decreases as pH increases; drugs that increase gastric pH are expected to decrease levels of ledipasvir; H2-receptor antagonists may be administered simultaneously with or 12 hr apart from ledipasvir/sofosbuvir at a dose that does not exceed doses comparable to famotidine 40 mg BID

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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