ibuprofen iv brand names and other generic formulations include:
Caldolor IV
methotrexate sodium inj brand names and other generic formulations include:
Mexate Inj, Mexate-aq Inj
ibuprofen iv and methotrexate sodium inj
ibuprofen iv increases levels of methotrexate sodium inj by reducing drug clearance through the kidneys. Combination may cause methotrexate toxicity.
ibuprofen iv and methotrexate sodium inj
ibuprofen iv increases levels of methotrexate sodium inj by decreasing renal clearance. Concomitant administration of NSAIDs with high dose methotrexate has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and GI toxicity. NSAIDs may reduce tubular secretion of methotrexate and enhance toxicity.
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant