Drug interactions with ibuprofen oral and methotrexate sodium inj

ibuprofen oral brand names and other generic formulations include:

Aches-N-Pain Oral, Advanced Pain Relief Oral, Advil Liqui-Gel Oral, Advil Migraine Oral, Advil Oral, A-G Profen Oral, Bayer Select Pain Relief Oral, Bupranol FP Oral, Cap-Profen Oral, Child Ibuprofen Oral, Children's Advil Oral, Children's Ibu-Drops Oral, Children's Ibuprofen Oral, Children's Medi-Profen Oral, Children's Motrin Jr Strength Oral, Children's Motrin Oral, Children's Profen IB Oral, Childs Ibuprofen Oral, Doan's Ibuprofen Oral, Dolgesic Oral, ElixSure IB Suspension Oral, Excedrin IB Oral, Genpril Oral, Haltran Oral, IB Pro Oral, Ibifon 600 Oral, Ibren Oral, IBU Oral, IBU-200 Oral, Ibu-Drops Oral, Ibumed-400 Oral, Ibumed-600 Oral, Ibupain-200 Oral, Ibuprin Oral, Ibuprofen IB Oral, Ibuprofen Jr Strength Oral, Ibuprofen M Oral, Ibuprofen PMR Oral, Ibuprohm Oral, Ibutab Oral, IBU-Tab Oral, Ibutex Oral, Ifen Oral, Infant's Advil Oral, Infants Ibu-Drops Oral, Infant's Ibuprofen Oral, Infant's Medi-Profen Oral, Infant's Motrin Oral, Infants ProfenIB Oral, I-Prin Oral, Medipren Oral, Menadol Oral, Midol (ibuprofen) Oral, Midol IB Oral, Midol Max St Cramp Formula Oral, Mofen Oral, Motrin IB Oral, Motrin Junior Strength Oral, Motrin Migraine Oral, Motrin Oral, Nuprin Menstrual Relief Oral, Nuprin Oral, Pamprin-IB Oral, PediaCare Fever Oral, Pedia-Profen Oral, Profen IB Oral, Profen-400 Oral, Provil Oral, Q-Profen Oral, Rufen Oral, Saleto-200 Oral, Saleto-400 Oral, Saleto-600 Oral, Saleto-800 Oral, Superior Pain Medicine Oral, Tab-Profen Oral, Uni-Pro Oral, Wal-Profen Oral, Yaprofen Oral

All generic drug interactions for ibuprofen oral (lists will include brand and generic names):

methotrexate sodium inj brand names and other generic formulations include:

Mexate Inj, Mexate-aq Inj

All generic drug interactions for methotrexate sodium inj (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

ibuprofen oral and methotrexate sodium inj

ibuprofen oral increases levels of methotrexate sodium inj by reducing drug clearance through the kidneys. Combination may cause methotrexate toxicity.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Serious - Use AlternativeAvoid or Use Alternate Drug.

ibuprofen oral and methotrexate sodium inj

ibuprofen oral increases levels of methotrexate sodium inj by decreasing renal clearance. Concomitant administration of NSAIDs with high dose methotrexate has been reported to elevate and prolong serum methotrexate levels, resulting in deaths from severe hematologic and GI toxicity. NSAIDs may reduce tubular secretion of methotrexate and enhance toxicity.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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