Drug interactions with itraconazole oral and lumacaftor-ivacaftor oral

itraconazole oral brand names and other generic formulations include:

Onmel Oral, Sporanox Oral, Sporanox Pulsepak Oral

All generic drug interactions for itraconazole oral (lists will include brand and generic names):

lumacaftor-ivacaftor oral brand names and other generic formulations include:

Orkambi Oral

All generic drug interactions for lumacaftor-ivacaftor oral (lists will include brand and generic names):
Monitor CloselyPotential for significant interaction (monitoring by your doctor is likely required)

itraconazole oral and lumacaftor-ivacaftor oral

itraconazole oral increases levels of lumacaftor-ivacaftor oral by altering drug metabolism. Combination increases blood levels of ivacaftor.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Monitor CloselyModify Therapy/Monitor Closely.

itraconazole oral and lumacaftor-ivacaftor oral

itraconazole oral increases levels of lumacaftor-ivacaftor oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Strong CYP3A inhibitors do not impact lumacaftor exposure, but increased ivacaftor exposure by 4.3-fold. Due to the induction effect of lumacaftor on CYP3A, at steady-state the net exposure of ivacaftor is not expected to exceed that when given in the absence of lumacaftor at a dose of 150 mg q12hr (the approved dose of ivacaftor monotherapy). Therefore, no dose adjustment is necessary when CYP3A inhibitors are initiated in patients currently taking lumacaftor/ivacaftor. However, when initiating lumacaftor/ivacaftor in patients taking strong CYP3A inhibitors, reduce the dose to 1 tablet daily (lumacaftor 200 mg/ivacaftor 125 mg total daily dose) for the first week of treatment to allow for the steady-state induction effect of lumacaftor. Following this period, continue with the recommended daily dose. No dose adjustment is required for moderate or weak CYP3A4 inhibitors.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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