Drug interactions with itraconazole oral and methadone inj

itraconazole oral brand names and other generic formulations include:

Onmel Oral, Sporanox Oral, Sporanox Pulsepak Oral

All generic drug interactions for itraconazole oral (lists will include brand and generic names):

methadone inj brand names and other generic formulations include:

Dolophine Inj

All generic drug interactions for methadone inj (lists will include brand and generic names):
ContraindicatedNever use this combination of drugs because of high risk for dangerous interaction

itraconazole oral and methadone inj

itraconazole oral will increase the level or effect of methadone inj by altering drug metabolism. Both drugs will increase abnormal heart beats (QT interval).

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
ContraindicatedContraindicated.

itraconazole oral and methadone inj

itraconazole oral will increase the level or effect of methadone inj by affecting hepatic/intestinal enzyme CYP3A4 metabolism. QT interval prolongation and serious arrhythmia (torsades de pointes) have occurred in patients using methadone concomitantly with oral itraconazole and/or other CYP3A4 inhibitors.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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