
itraconazole oral brand names and other generic formulations include:
Onmel Oral, Sporanox Oral, Sporanox Pulsepak Oral
netupitant-palonosetron oral brand names and other generic formulations include:
Akynzeo Oral
itraconazole oral and netupitant-palonosetron oral
itraconazole oral will increase the level or effect of netupitant-palonosetron oral by altering drug metabolism. Blood levels of netupitant may be increased.
itraconazole oral and netupitant-palonosetron oral
itraconazole oral will increase the level or effect of netupitant-palonosetron oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Netupitant is mainly metabolized by CYP3A4; no dosage adjustment is required
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant