lansoprazole iv brand names and other generic formulations include:
clopidogrel oral brand names and other generic formulations include:
lansoprazole iv and clopidogrel oral
lansoprazole iv decreases effects of clopidogrel oral by altering drug metabolism. Combination may interfere with the effect of clopidogrel.
lansoprazole iv and clopidogrel oral
lansoprazole iv decreases effects of clopidogrel oral by affecting hepatic enzyme CYP2C19 metabolism. Mean AUC of clopidogrel active metabolite was reduced by ~14% when lansoprazole was coadministered compared to administration of clopidogrel alone in healthy subjects who were CYP2C19 extensive metabolizers. Clopidogrel efficacy may be reduced by drugs that inhibit CYP2C19. Inhibition of platelet aggregation by clopidogrel is entirely due to the active clopidogrel metabolite. Clopidogrel is metabolized in part by CYP2C19
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant