Drug interactions with leflunomide oral and methotrexate sodium oral

leflunomide oral brand names and other generic formulations include:

Arava Oral

All generic drug interactions for leflunomide oral (lists will include brand and generic names):

methotrexate sodium oral brand names and other generic formulations include:

Methotrexate (Anti-Rheumatic) Oral, Rheumatrex Oral, Trexall Oral

All generic drug interactions for methotrexate sodium oral (lists will include brand and generic names):
Monitor CloselyPotential for significant interaction (monitoring by your doctor is likely required)

leflunomide oral and methotrexate sodium oral

leflunomide oral increases levels of methotrexate sodium oral by unspecified interaction mechanism.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Monitor CloselyModify Therapy/Monitor Closely.

leflunomide oral and methotrexate sodium oral

leflunomide oral increases levels of methotrexate sodium oral by unspecified interaction mechanism. Additive hepatotoxicity, pancytopenia. If leflunomide and methotrexate are given concomitantly, monitor liver toxicity with ALT, AST, and serum albumin testing. Also, monitor platelets, WBC count, hemoglobin, or hematocrit at baseline and monthly for 6 months following initiation and every 6-8 weeks thereafter.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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