Drug interactions with naltrexone-bupropion oral and promethazine-codeine oral

naltrexone-bupropion oral brand names and other generic formulations include:

Contrave Oral

All generic drug interactions for naltrexone-bupropion oral (lists will include brand and generic names):

promethazine-codeine oral brand names and other generic formulations include:

Chemergan-Codeine Oral, Dectuss C Oral, Phenergan-Codeine Oral

All generic drug interactions for promethazine-codeine oral (lists will include brand and generic names):
Monitor CloselySignificant interaction possible (monitoring by your doctor required)

naltrexone-bupropion oral and promethazine-codeine oral

naltrexone-bupropion oral will decrease the level or effect of promethazine-codeine oral by altering drug metabolism. Conversion of codeine to it's active form is reduced, possibly reducing the effect of codeine.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Monitor CloselyUse Caution/Monitor.

naltrexone-bupropion oral and promethazine-codeine oral

naltrexone-bupropion oral will decrease the level or effect of promethazine-codeine oral by affecting hepatic enzyme CYP2D6 metabolism. Prevents the conversion of codeine to its active metabolite morphine.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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