Drug interactions with netupitant-palonosetron oral and guanfacine oral

netupitant-palonosetron oral brand names and other generic formulations include:

Akynzeo Oral

All generic drug interactions for netupitant-palonosetron oral (lists will include brand and generic names):

guanfacine oral brand names and other generic formulations include:

Intuniv ER Oral, Tenex Oral

All generic drug interactions for guanfacine oral (lists will include brand and generic names):
Monitor CloselyPotential for significant interaction (monitoring by your doctor is likely required)

netupitant-palonosetron oral and guanfacine oral

netupitant-palonosetron oral will increase the level or effect of guanfacine oral by altering drug metabolism. Blood levels of guanfacine may increase. The dose of extended release guanfacine should be reduced by half.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Monitor CloselyModify Therapy/Monitor Closely.

netupitant-palonosetron oral and guanfacine oral

netupitant-palonosetron oral will increase the level or effect of guanfacine oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Strong or moderate CYP3A4 inhibitors significantly increase guanfacine plasma concentrations. FDA-approved labeling for extended-release (ER) guanfacine recommends that, if coadministered, the guanfacine dosage should be decreased to half of the recommended dose. Specific recommendations for immediate-release (IR) guanfacine are not available.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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