
nicardipine iv brand names and other generic formulations include:
Cardene IV
ponatinib oral brand names and other generic formulations include:
Iclusig Oral
nicardipine iv and ponatinib oral
nicardipine iv increases levels of ponatinib oral by altering drug metabolism. Starting dose of ponatinib should be reduced to 30 mg daily.
nicardipine iv and ponatinib oral
nicardipine iv increases levels of ponatinib oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Decrease ponatinib starting dose to 30 mg qDay if coadministration with strong CYP3A4 inhibitors cannot be avoided
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant