Drug interactions with nilotinib oral and riociguat oral

nilotinib oral brand names and other generic formulations include:

Tasigna Oral

All generic drug interactions for nilotinib oral (lists will include brand and generic names):

riociguat oral brand names and other generic formulations include:

Adempas Oral

All generic drug interactions for riociguat oral (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

nilotinib oral and riociguat oral

nilotinib oral will increase the level or effect of riociguat oral by slowing drug metabolism. Combination may increase blood levels of riociguat, requiring a reduced dose of riociguat. Your doctor will monitor for low blood pressure (hypotension).

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Serious - Use AlternativeAvoid or Use Alternate Drug.

nilotinib oral and riociguat oral

nilotinib oral will increase the level or effect of riociguat oral by decreasing metabolism. Coadministration of riociguat (substrate of CYP isoenzymes 1A1, 2C8, 3A, 2J2) with strong CYP inhibitors may require a decreased initial dose of 0.5 mg PO TID; monitor for signs of hypotension and reduce dose if needed

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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