Drug interactions with phenobarbital oral and ivacaftor oral

phenobarbital oral brand names and other generic formulations include:

Barbita Oral, Neuroval Oral, Sk-Phenobarbital Oral, Solfoton Oral

All generic drug interactions for phenobarbital oral (lists will include brand and generic names):

ivacaftor oral brand names and other generic formulations include:

Kalydeco Oral

All generic drug interactions for ivacaftor oral (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required

phenobarbital oral and ivacaftor oral

phenobarbital oral decreases levels of ivacaftor oral by altering drug metabolism. Blood levels of ivacaftor may be reduced by 9 fold.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Serious - Use AlternativeAvoid or Use Alternate Drug.

phenobarbital oral and ivacaftor oral

phenobarbital oral decreases levels of ivacaftor oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid coadministration with strong CYP3A4 inducers; systemic exposure of ivacaftor substantially reduced (ie, ~9-fold)

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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