Drug interactions with pioglitazone-metformin oral and estradiol valerate-dienogest oral

pioglitazone-metformin oral brand names and other generic formulations include:

Actoplus MET Oral, Actoplus Met XR Oral

All generic drug interactions for pioglitazone-metformin oral (lists will include brand and generic names):

estradiol valerate-dienogest oral brand names and other generic formulations include:

Natazia Oral

All generic drug interactions for estradiol valerate-dienogest oral (lists will include brand and generic names):
Monitor CloselyPotential for interaction

pioglitazone-metformin oral and estradiol valerate-dienogest oral

pioglitazone-metformin oral will decrease the level or effect of estradiol valerate-dienogest oral by altering drug metabolism. Extreme caution; Patients should use alternative birth-control methods; back-up contraception should be continued for 28 days after discontinuing medication to ensure contraceptive reliability.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Monitor CloselyUse Caution/Monitor.

pioglitazone-metformin oral and estradiol valerate-dienogest oral

pioglitazone-metformin oral will decrease the level or effect of estradiol valerate-dienogest oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Advise women to use alternative method of contraception or back-up method when moderate or weak enzyme inducer is used with combination contraceptives. Back-up contraception should be continued for 28 days after discontinuing medication to ensure contraceptive reliability.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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