Drug interactions with pioglitazone-metformin oral and ifosfamide iv

pioglitazone-metformin oral brand names and other generic formulations include:

Actoplus MET Oral, Actoplus Met XR Oral

All generic drug interactions for pioglitazone-metformin oral (lists will include brand and generic names):

ifosfamide iv brand names and other generic formulations include:

Ifex IV

All generic drug interactions for ifosfamide iv (lists will include brand and generic names):
Monitor CloselySignificant interaction possible (monitoring by your doctor required)

pioglitazone-metformin oral and ifosfamide iv

pioglitazone-metformin oral increases toxicity of ifosfamide iv by altering drug metabolism.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Monitor CloselyUse Caution/Monitor.

pioglitazone-metformin oral and ifosfamide iv

pioglitazone-metformin oral increases toxicity of ifosfamide iv by affecting hepatic/intestinal enzyme CYP3A4 metabolism. CYP3A4 inducers may increase the metabolism of ifosfamide to its active alkylating metabolites. CYP3A4 inducers may increase the formation of the neurotoxic/nephrotoxic ifosfamide metabolite, chloroacetaldehyde. Closely monitor patients taking ifosfamide with CYP3A4 inducers for toxicities and consider dose adjustment.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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