Drug interactions with rabeprazole oral and ledipasvir-sofosbuvir oral

rabeprazole oral brand names and other generic formulations include:

Aciphex Oral, AcipHex Sprinkle Oral

All generic drug interactions for rabeprazole oral (lists will include brand and generic names):

ledipasvir-sofosbuvir oral brand names and other generic formulations include:

Harvoni Oral

All generic drug interactions for ledipasvir-sofosbuvir oral (lists will include brand and generic names):
Monitor CloselySignificant interaction possible (monitoring by your doctor required)

rabeprazole oral and ledipasvir-sofosbuvir oral

rabeprazole oral decreases levels of ledipasvir-sofosbuvir oral by Other mechanism. Blood levels of ledipasvir may decrease.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Monitor CloselyUse Caution/Monitor.

rabeprazole oral and ledipasvir-sofosbuvir oral

rabeprazole oral decreases levels of ledipasvir-sofosbuvir oral by Other (see comment). Ledipasvir solubility decreases as pH increases; drugs that increase gastric pH are expected to decrease levels of ledipasvir; proton-pump inhibitor doses comparable to omeprazole <20 mg can be administered simultaneously with ledipasvir/sofosbuvir under fasted conditions

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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