Drug interactions with rifampin-isoniazid oral and afatinib oral

rifampin-isoniazid oral brand names and other generic formulations include:

IsonaRif Oral, Rifamate Oral

All generic drug interactions for rifampin-isoniazid oral (lists will include brand and generic names):

afatinib oral brand names and other generic formulations include:

Gilotrif Oral

All generic drug interactions for afatinib oral (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

rifampin-isoniazid oral and afatinib oral

rifampin-isoniazid oral decreases levels of afatinib oral by affects how the drug is eliminated from the body (via what is known as the P-glycoprotein [MDR1] transporter). Your doctor may increase afatinib daily dose by 10 mg if chronic therapy with this combination is necessary.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Serious - Use AlternativeAvoid or Use Alternate Drug.

rifampin-isoniazid oral and afatinib oral

rifampin-isoniazid oral decreases levels of afatinib oral by P-glycoprotein (MDR1) efflux transporter. Increase afatinib daily dose by 10 mg as tolerated if chronic therapy with P-gp inducer required; resume previous afatinib dose 2-3 days after P-gp inducer discontinued

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

Check for more interactions with the Drug Interaction Checker

Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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