
rifampin-isoniazid oral brand names and other generic formulations include:
IsonaRif Oral, Rifamate Oral
ibuprofen-oxycodone oral brand names and other generic formulations include:
rifampin-isoniazid oral and ibuprofen-oxycodone oral
rifampin-isoniazid oral increases levels of ibuprofen-oxycodone oral by altering drug metabolism. Combination increases risk of side effects; your doctor may reduce the dose of oxycodone when taken in this combination.
rifampin-isoniazid oral and ibuprofen-oxycodone oral
rifampin-isoniazid oral increases levels of ibuprofen-oxycodone oral by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Oxycodone dose reduction may be warranted when coadministered with strong CYP3A4 inhibitors
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant