Drug interactions with rifampin-isoniazid oral and pirfenidone oral

rifampin-isoniazid oral brand names and other generic formulations include:

IsonaRif Oral, Rifamate Oral

All generic drug interactions for rifampin-isoniazid oral (lists will include brand and generic names):

pirfenidone oral brand names and other generic formulations include:

Esbriet Oral

All generic drug interactions for pirfenidone oral (lists will include brand and generic names):
ContraindicatedNever use this combination of drugs because of high risk for dangerous interaction

rifampin-isoniazid oral and pirfenidone oral

rifampin-isoniazid oral will decrease the level or effect of pirfenidone oral by altering drug metabolism. Before taking pirfenidone you should stop taking the other drug and avoid it during pirfenidone treatment.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
ContraindicatedContraindicated.

rifampin-isoniazid oral and pirfenidone oral

rifampin-isoniazid oral will decrease the level or effect of pirfenidone oral by affecting hepatic enzyme CYP1A2 metabolism. Use of strong CYP1A2 inducers should be discontinued before initiating pirfenidone and avoided during treatment

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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