Drug interactions with rolapitant oral and pimozide oral

rolapitant oral brand names and other generic formulations include:

Varubi Oral

All generic drug interactions for rolapitant oral (lists will include brand and generic names):

pimozide oral brand names and other generic formulations include:

Orap Oral

All generic drug interactions for pimozide oral (lists will include brand and generic names):
ContraindicatedNever use this combination of drugs because of high risk for dangerous interaction

rolapitant oral and pimozide oral

rolapitant oral will increase the level or effect of pimozide oral by altering drug metabolism. This combination increases blood levels of pimozide and the risk of abnormal heart beats.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
ContraindicatedContraindicated.

rolapitant oral and pimozide oral

rolapitant oral will increase the level or effect of pimozide oral by affecting hepatic enzyme CYP2D6 metabolism. Rolapitant moderately inhibits CYP2D6. Coadministration with pimozide, a CYP2D6 substrate, causes a significant increase in pimozide plasma concentration that may result in QT prolongation and torsades de pointes.

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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