
sildenafil oral brand names and other generic formulations include:
riociguat oral brand names and other generic formulations include:
Adempas Oral
sildenafil oral and riociguat oral
sildenafil oral , riociguat oral . Either increases the level of the other by blood pressure lowering effect that may lead to fainting. Risk of low blood pressure (hypotension); combination should be avoided.
sildenafil oral and riociguat oral
sildenafil oral , riociguat oral . Either increases effects of the other by additive vasodilation. Coadministration of PDE-5 inhibitors (eg, avanafil, sildenafil, tadalafil, vardenafil) and guanylate cyclase stimulators (eg, riociguat) is contraindicated due to risk of additive hypotension; do not administer within 24 hr of each other.
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Drug Interaction Categories
Contraindicated
Never use this combination of drugs because of high risk for dangerous interaction
Serious
Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed
Significant
Potential for significant interaction (monitoring by your doctor is likely required)
Minor
Interaction is unlikely, minor, or nonsignificant