Drug interactions with spironolactone-hydrochlorothiazide oral and cyclophosphamide iv

spironolactone-hydrochlorothiazide oral brand names and other generic formulations include:

Aldactazide Oral, Aldarex Plus Oral, Altexide Oral, Decozide Oral, Hydrotone Oral, Spirochlor Oral, Spironazide Oral, Spirozide Oral

All generic drug interactions for spironolactone-hydrochlorothiazide oral (lists will include brand and generic names):

cyclophosphamide iv brand names and other generic formulations include:

Cytoxan IV, Cytoxan Lyophilized IV, Neosar IV

All generic drug interactions for cyclophosphamide iv (lists will include brand and generic names):
Serious - Use AlternativePotential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

spironolactone-hydrochlorothiazide oral and cyclophosphamide iv

spironolactone-hydrochlorothiazide oral increases toxicity of cyclophosphamide iv by reducing drug clearance through the kidneys. The effect of elbasvir/grazoprevir may be reduced. This combination should be avoided.

Patient Drug Interactions Source: RxList
© 2023 RxList, Inc.
Serious - Use AlternativeAvoid or Use Alternate Drug.

spironolactone-hydrochlorothiazide oral and cyclophosphamide iv

spironolactone-hydrochlorothiazide oral increases toxicity of cyclophosphamide iv by decreasing renal clearance. Increased myelosuppressive effects

Clinical Drug Interactions Source: Medscape from WebMD
© 1994-2023 WebMD, LLC.

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Drug Interaction Categories

Contraindicated

Never use this combination of drugs because of high risk for dangerous interaction

Serious

Potential for serious interaction; regular monitoring by your doctor required or alternate medication may be needed

Significant

Potential for significant interaction (monitoring by your doctor is likely required)

Minor

Interaction is unlikely, minor, or nonsignificant

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The information provided here is for informational purposes only. This tool may not cover all possible drug interactions. Please check with a physician if you have health questions or concerns. Although we attempt to provide accurate and up-to-date information, no guarantee is made to that effect.

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